Search results for "Cell morphogenesis"

showing 3 items of 3 documents

Synthesis of tumor-associated glycopeptide antigens.

2002

Carbohydrates and peptides linked together in glycoproteins constitute important components of the molecular communication between cells in multicellular organisms. Cell morphogenesis and tumorigenesis are accompanied by changes in the glycoprotein profiles of the outer cell membranes. Glycopeptide fragments of glycoproteins that have altered structures in tumor cells are of interest as tumor-associated antigens for the distinction between normal cells and tumor cells. In contrast to glycoproteins isolated from biological sources, synthetic glycopeptides are obtained in pure form and exactly specified structures. The methods developed for the synthesis of glycopeptides with tumor-associated…

GlycosylationStereochemistryClinical BiochemistryPharmaceutical ScienceOligosaccharidesBiochemistrychemistry.chemical_compoundLewis Blood Group AntigensDrug DiscoveryHumansAntigens Tumor-Associated CarbohydrateAntigens Viral TumorMolecular Biologychemistry.chemical_classificationCell morphogenesisOrganic ChemistryGlycopeptidesSialyl-Lewis AGlycopeptideSialic acidAmino acidSialyl-Lewis XchemistryBiochemistrySialic AcidsMolecular MedicineGlycoproteinBioorganicmedicinal chemistry
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Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase

2011

Abstract In our prior studies ( Orr et al., 2005 ) we achieved a 30–50% increase in the life span of Drosophila by manipulating glutathione (GSH) production in neuronal tissues, through over-expression of glutamate-cysteine ligase (GCL), a key enzyme in glutathione biosynthesis. In the present study, we identified gene response patterns from which plausible mechanisms responsible for the observed effects on life span might be inferred. Functional clustering analysis of the transcriptome data revealed that biological processes affected by GCLc in young flies (10 days) were generally related to cell morphogenesis and differentiation, while those in older flies were associated with nucleosome …

Nucleosome organizationAgingGlutamate-Cysteine LigaseLongevityBiologyTranscriptomechemistry.chemical_compoundTranscription (biology)MorphogenesisAnimalsGeneOligonucleotide Array Sequence AnalysisGeneticschemistry.chemical_classificationDNA ligaseCell morphogenesisGene Expression ProfilingfungiCell DifferentiationGlutathioneGlutathioneImmunity HumoralNucleosomesDrosophila melanogasterGCLCchemistryDevelopmental BiologyMechanisms of Ageing and Development
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ChemInform Abstract: Synthesis of Tumor-Associated Glycopeptide Antigens

2010

Carbohydrates and peptides linked together in glycoproteins constitute important components of the molecular communication between cells in multicellular organisms. Cell morphogenesis and tumorigenesis are accompanied by changes in the glycoprotein profiles of the outer cell membranes. Glycopeptide fragments of glycoproteins that have altered structures in tumor cells are of interest as tumor-associated antigens for the distinction between normal cells and tumor cells. In contrast to glycoproteins isolated from biological sources, synthetic glycopeptides are obtained in pure form and exactly specified structures. The methods developed for the synthesis of glycopeptides with tumor-associated…

chemistry.chemical_classificationchemistry.chemical_compoundGlycosylationSialyl-Lewis XchemistryBiochemistryCell morphogenesisGeneral MedicineSialyl-Lewis AGlycoproteinGlycopeptideAmino acidSialic acidChemInform
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